Impact of Biological Coatings on Nanoparticle-Immune Cell Interactions

Influence of hydrophilic polymers on the accelerated blood clearance of mRNA lipid nanoparticles upon repeated administration

DNBP Hassanel, Y Ju, A Takanashi, A Algarni, CL Lee, SJ Kent, CW Pouton, EH Pilkington

2025-12-01

mRNA lipid nanoparticles (LNPs) have emerged as a leading delivery system for mRNA-based vaccines and therapeutics. However, a sig..

Polyphenol-Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases.

Shiyao Li, Patrick Charchar, Haitao Yu, Zhixing Lin, Hamish G Brown, Wanjun Xu, Chan-Jin Kim, Irene Yarovsky, Yi Ju, Frank Caruso

2025-09-15

Lipids self-assemble into lipid nanoparticles (LNPs) with different crystalline mesophases, including lamellar and nonlamellar (e...

Polyphenol-Mediated Antibody Functionalization of Titanium Peroxide Nanoparticles for Cancer Cell Targeting

Hiroaki Akasaka, Makiko Nakahana, Masao Nakayama, Kenta Morita, Mohammed Salah, Naritoshi Mukumoto, Yasuyuki Shimizu, Ruixain Zhangzhu, Chiaki Ogino, Christina Cortez-Jugo, Joseph J Richardson, Frank Caruso, Ryohei Sasaki

2025-01-01

Cell targeting would benefit various biotechnological applications such as disease diagnosis and cancer therapy. However, efficien..

Approaching Two Decades: Biomolecular Coronas and Bio-Nano Interactions

S Li, C Cortez-Jugo, Y Ju, F Caruso

2024-12-10

It has been nearly two decades since the term “protein corona” was coined. This term has since evolved to “biomolecular corona” or..

Patient-Specific Nanoparticle Targeting in Human Leukemia Blood

Y Ju, S Li, AEQ Tan, EH Pilkington, PT Brannon, M Plebanski, J Cui, F Caruso, KJ Thurecht, C Tam, SJ Kent

2024-10-22

Antibody-directed targeting of chemotherapeutic nanoparticles to primary human cancers holds promise for improving efficacy and re..

Blood Distribution of SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine in Humans

SJ Kent, S Li, TH Amarasena, A Reynaldi, WS Lee, MG Leeming, DH O’Connor, J Nguyen, HE Kent, F Caruso, JA Juno, AK Wheatley, MP Davenport, Y Ju

2024-10-01

Lipid nanoparticle mRNA vaccines are an exciting but emerging technology used in humans. There is limited understanding of the fac..

Engineering poly(ethylene glycol) particles for targeted drug delivery

S Li, Y Ma, J Cui, F Caruso, Y Ju

2024-01-23

Poly(ethylene glycol) (PEG) is considered to be the “gold standard” among the stealth polymers employed for drug delivery. Using P..

Metal-phenolic network composites: from fundamentals to applications

Zhixing Lin, Hai Liu, Joseph J Richardson, Wanjun Xu, Jingqu Chen, Jiajing Zhou, Frank Caruso

2024-01-01

Composites with tailored compositions and functions have attracted widespread scientific and industrial interest. Metal–phenolic n..

Functional Ligand-Enabled Particle Assembly for Bio-Nano Interactions

Y Ju, CJ Kim, F Caruso

2023-07-04

Functional ligands consist of a wide range of small or large molecules that exhibit a spectrum of physical, chemical, and biologic..

Poly(ethylene glycol) Cross-Linked Antibody Nanoparticles for Tunable Biointeractions

Yingjie Hu, Christina Cortez-Jugo, Yi Ju, Tian Zheng, Jiajing Zhou, Zhixing Lin, Robert De Rose, Christoph E Hagemeyer, Karen Alt, Frank Caruso

2023-01-01

Liver accumulation of nanoparticles is a major challenge in nanoparticle-mediated delivery as it can reduce the delivery of the na..

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Y Ju, WS Lee, EH Pilkington, HG Kelly, S Li, KJ Selva, KM Wragg, K Subbarao, THO Nguyen, LC Rowntree, LF Allen, K Bond, DA Williamson, NP Truong, M Plebanski, K Kedzierska, S Mahanty, AW Chung, F Caruso, AK Wheatley

2022-08-23

Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) m..

Protein precoating modulates biomolecular coronas and nanocapsule-immune cell interactions in human blood

S Li, Y Ju, J Zhou, M Faria, CS Ang, AJ Mitchell, QZ Zhong, T Zheng, SJ Kent, F Caruso

2022-06-09

The biomolecular corona that forms on particles upon contact with blood plays a key role in the fate and utility of nanomedicines...

Nanostructured particles assembled from natural building blocks for advanced therapies

Y Ju, H Liao, JJ Richardson, J Guo, F Caruso

2022-04-26

Advanced treatments based on immune system manipulation, gene transcription and regulation, specific organ and cell targeting, and..